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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RUNX1 All Species: 13.64
Human Site: S212 Identified Species: 30
UniProt: Q01196 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.3
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q01196 NP_001001890.1 453 48737 S212 R R T A M R V S P H H P A P T
Chimpanzee Pan troglodytes XP_531447 467 50347 S226 R R T A M R V S P H H P A P T
Rhesus Macaque Macaca mulatta XP_001087338 453 48702 S212 R R T A M R V S P H H P A P T
Dog Lupus familis XP_858942 453 48730 S212 R R T A M R V S P H H P A P T
Cat Felis silvestris
Mouse Mus musculus Q03347 451 48591 V211 L R R T A M R V S P H H P A P
Rat Rattus norvegicus Q63046 450 48538 R210 Q L R R T A M R V S P H H P A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_989459 472 51671 R231 R I P H P S M R V G V P T Q S
Frog Xenopus laevis Q6PF39 462 50351 M219 S P H H P N P M P N P R A T L
Zebra Danio Brachydanio rerio NP_571678 451 48407 R209 Q L R R S A M R C S P H H G P
Tiger Blowfish Takifugu rubipres NP_001027815 463 50317 V221 S E L E R M R V R V A V P T Q
Fruit Fly Dros. melanogaster Q9W349 826 84703 A468 A A N A V A A A A A A V A V T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.5 99.7 98.9 N.A. 95.5 95.3 N.A. N.A. 65 87.6 72.8 63.7 24.2 N.A. N.A. N.A.
Protein Similarity: 100 96.7 100 99.5 N.A. 96.4 96.2 N.A. N.A. 75.6 91.3 80.5 77.1 32.9 N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 13.3 6.6 N.A. N.A. 13.3 13.3 0 0 20 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 13.3 20 N.A. N.A. 26.6 20 13.3 0 33.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 0 46 10 28 10 10 10 10 19 0 55 10 10 % A
% Cys: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 10 0 10 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 10 0 0 0 10 0 % G
% His: 0 0 10 19 0 0 0 0 0 37 46 28 19 0 0 % H
% Ile: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 10 19 10 0 0 0 0 0 0 0 0 0 0 0 10 % L
% Met: 0 0 0 0 37 19 28 10 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 0 0 10 0 0 0 10 0 0 0 0 0 % N
% Pro: 0 10 10 0 19 0 10 0 46 10 28 46 19 46 19 % P
% Gln: 19 0 0 0 0 0 0 0 0 0 0 0 0 10 10 % Q
% Arg: 46 46 28 19 10 37 19 28 10 0 0 10 0 0 0 % R
% Ser: 19 0 0 0 10 10 0 37 10 19 0 0 0 0 10 % S
% Thr: 0 0 37 10 10 0 0 0 0 0 0 0 10 19 46 % T
% Val: 0 0 0 0 10 0 37 19 19 10 10 19 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _